Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model

Code for the publication "Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model" Hartmann et al. 2022 in Cancer Letters.

All scripts are provided as they were run for the publication. Processing of the data followed standard protocols as described in the methods of the publication. The raw and processed data are deposited in GEO (GSE214524) under the BioProject PRJNA884506.

This includes the mapped CellRanger outputs:

• untreated control: GSM6610518
• C12 in-field tumor: GSM6610517
• C12 out-of-field tumor: GSM6610520
• C12+anti-CTLA4 in-field tumor: GSM6610519
• C12+anti-CTLA4 out-of-field tumor: GSM6610516

Furthermore, this includes the processed and annotated Seurat objects:

• All cells (download link)
• Lymphoid cells (download link)
• Myeloid cells (download link)

For questions please write an issue, contact me via oliver.eichmueller@imba.oeaw.ac.at, or contact the corresponding author.