create a virtual environment (or don't)
run pip install -r requirements.txt
run the app.py script and you should be good to go!
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Simply toggle on this line and comment out this line and start the app.py script. You should now see an OS-native window with the app running inside it.
If you've got any other questions such as "how do I convert my Flask desktop app into an executable?" feel free to create an issue and I'll write something up for that!