Codes for Statistical Analysis of Medical Data course instructed by Dr. Zahra Ghanbari in Fall 2022 @ Amirkabir University of Technology.
The code consists of performing a set of statistical tests on the MRI anatomic volume results from OASIS-2 dataset and visualizing the distribution of them among different subject groups. The goal was to find a relationship between the size of nWBV (normalized whole-brain volume) and dementia level (non-demented, demented, and converted) and to see whether subjects classified as demented or converted (converted to demented over the study period) have a smaller nWBV on average compared to the non-demented group. In the The OASIS-2 dataset is a collection of longitudinal brain MRI scans from 150 subjects aged 60 to 96. The scans for each subject were acquired during their yearly visits. Since the number of visits for each subject was different, the latest nWBV results were only used.
Daniel S. Marcus, Anthony F. Fotenos, John G. Csernansky, John C. Morris, Randy L. Buckner; Open Access Series of Imaging Studies: Longitudinal MRI Data in Nondemented and Demented Older Adults. J Cogn Neurosci 2010; 22 (12): 2677–2684. doi: https://doi.org/10.1162/jocn.2009.21407