AL_hiPSC_ionic_model

Introduction

This MATLAB (The MathWorks, Natick, MA) source code provides an implementation of a phenotype-specific ionic model for matured and paced atrial-like hiPSC-CMs integrating the atrial-specific IKur and IKCa currents.

Software Requirements

• MATLAB R2022a or later versions
• Any additional Toolbox required

Main Contributors

• Dr. Sofia Botti (Euler Institute, USI - Department of Mathematics, UNIPV)
• Dr. Chiara Bartolucci (Department of Engineering, UNIBO)
• Dr. Rolf Krause (Euler Institute, USI - Department of Mathematics, UNIDISTANCE)
• Dr. Luca Franco Pavarino (Department of Mathematics, UNIPV)
• Dr. Stefano Severi (Department of Engineering, UNIBO)

License

The software is provided with NO WARRANTY and is licensed under the BSD 2-Clause "Simplified" License.

How to Run

• Run the main file main_Botti2024.m for the simulation of 10 seconds of the presented ionic model with pacing at 1 Hertz.
• To obtain a spontaneous beating behavior, change the stimFlag at line 50 of main_Botti2024.m, and change the IK1 conductance setting gK1 = 0.05 at line 214 of the function file Botti2024.m to run the simulation for 10 seconds of the presented ionic model without pacing.

Citing This Code

When using this ionic model, please cite the following manuscript:

@article{Botti2024,
  author = {Sofia Botti and Chiara Bartolucci and Claudia Altomare and Michelangelo Paci and Lucio Barile and Rolf Krause and Luca Franco Pavarino and Stefano Severi}
  title = {A novel ionic model for matured and paced atrial-like human iPSC-CMs integrating IKur and IKCa currents},
  journal = {Computers in Biology and Medicine},
  volume = {180},
  pages = {108899},
  year = {2024},
  issn = {0010-4825},
  doi = {https://doi.org/10.1016/j.compbiomed.2024.108899},
}
}