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This model was developed integrating a modified version of the L-type Ca current (LTCC) model by Mahajan et al. (Biophys J. 2008 Jan 15;94(2):392 -410) into the framework of the Shannon-Bers rabbit ventricular model (Biophys J. 2004 Nov;87(5):3351-71). The LTCC model was extended to reflect more faithfully contributions of Ca- and voltage-depend…
drgrandilab/Morotti-et-al-2012-Rabbit-Ventricular-Model-with-Updated-ICaL
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Matlab code of the Morotti et al. model of rabbit ventricular myocyte with updated ICaL formulation This model was developed integrating a modified version of the L-type Ca current (LTCC) model by Mahajan et al. (Biophys J. 2008 Jan 15;94(2):392 -410) into the framework of the Shannon-Bers rabbit ventricular model (Biophys J. 2004 Nov;87(5):3351-71, available for download in this website). The LTCC model was extended to reflect more faithfully contributions of Ca- and voltage-dependent inactivation (CDI and VDI) to total inactivation. Reference: S. Morotti, E. Grandi, A. Summa, K.S. Ginsburg, D.M. Bers. Theoretical Study of L-type Ca2+ Current Inactivation Kinetics during Action Potential Repolarization and Early Afterdepolarizations. J Physiol. 2012 Sep 15;590(Pt 18):4465-81. doi: https://doi.org/10.1113/jphysiol.2012.231886 Please cite the above paper when using this code.
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This model was developed integrating a modified version of the L-type Ca current (LTCC) model by Mahajan et al. (Biophys J. 2008 Jan 15;94(2):392 -410) into the framework of the Shannon-Bers rabbit ventricular model (Biophys J. 2004 Nov;87(5):3351-71). The LTCC model was extended to reflect more faithfully contributions of Ca- and voltage-depend…
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