Reprogram-Seq

Reprogram-Seq leverages organ-specific cell atlas data with single-cell perturbation and computational analysis to predict, evaluate, and optimize TF combinations that reprogram a cell type of interest.

Workflow

Code

To reproduce results:

• https://jlduan.github.io/Reprogram-Seq

Citation

Jialei Duan#, Boxun Li#, Minoti Bhakta#, Shiqi Xie, Pei Zhou, Nikhil V. Munshi*, Gary C. Hon* (2019). Rational Reprogramming of Cellular States by Combinatorial Perturbation. Cell Rep. 27, 3486–3499.e6.
DOI: http://dx.doi.org/10.1016/j.celrep.2019.05.079