fix: allow simphenotype to accept TR PGENs without --repeats

docs/api/data.rst

@@ -183,6 +183,8 @@ The following methods from the :class:`Genotypes` class are disabled, however.
 1. ``check_biallelic``
 2. ``check_maf``
 
+The constructor of the :class:`GenotypesTR` class also includes a :code:`vcftype` parameter. This can be helpful when the type of the TR file cannot be inferred automatically. Refer to `the TRTools docs <https://trtools.readthedocs.io/en/stable/trtools.utils.tr_harmonizer.html#trtools.utils.tr_harmonizer.VcfTypes>`_ for a list of accepted types.
+
 .. _api-data-genotypestr:
 
 GenotypesPLINK

docs/formats/genotypes.rst

@@ -37,3 +37,14 @@ To convert a VCF containing tandem repeats to PGEN, use this command, instead.
 .. code-block:: bash
 
 	plink2 --vcf-half-call m --make-pgen 'pvar-cols=vcfheader,qual,filter,info' --vcf input.vcf --make-pgen --out output
+
+Tandem repeats
+~~~~~~~~~~~~~~
+VCFs containing tandem repeats usually have a *type* indicating the tool from which they originated. We support whichever types are supported by `TRTools <https://trtools.readthedocs.io/en/stable/CALLERS.html>`_.
+
+We do our best to infer the *type* of a TR VCF automatically. However, there will be some instances when it cannot be inferred.
+Users of TRTools know to specify :code:`--vcftype` in that situation. However, most haptools commands do not yet support the :code:`--vcftype` parameter. Instead, you can modify the header of your VCF to trick haptools into being able to infer the *type*.
+
+For example, if you're using HipSTR, you can add :code:`##command=hipstr...`. Refer to `this code in TRTools <https://trtools.readthedocs.io/en/stable/trtools.utils.tr_harmonizer.html#trtools.utils.tr_harmonizer.InferVCFType>`_ for more details.
+
+Please note that all of this also applies to PVAR files created from TR VCFs.

haptools/sim_phenotype.py

@@ -405,8 +405,12 @@ def simulate_pt(
         # check if these are all repeat IDs, haplotype IDs, or a mix of them
         if len(hp.type_ids["R"]) >= len(haplotype_ids) and repeats is None:
             # if they're all repeat IDs or --repeats was specified
-            log.info("Loading TR genotypes")
-            gt = GenotypesTR(fname=genotypes, log=log)
+            if genotypes.suffix == ".pgen":
+                log.info("Loading TR genotypes from PGEN file")
+                gt = GenotypesPLINKTR(fname=genotypes, log=log, chunk_size=chunk_size)
+            else:
+                log.info("Loading TR genotypes from VCF/BCF file")
+                gt = GenotypesTR(fname=genotypes, log=log)
             load_as_haps = False
         else:
             # the genotypes variable must contain haplotype genotypes

tests/test_simphenotype.py

@@ -670,6 +670,17 @@ def test_repeat(self, capfd):
         assert captured.out
         assert result.exit_code == 0
 
+    def test_repeat_pgen(self, capfd):
+        gt_file = DATADIR / "simple-tr.pgen"
+        hp_file = DATADIR / "simple_tr.hap"
+
+        cmd = f"simphenotype --id 1:10114:GTT {gt_file} {hp_file}"
+        runner = CliRunner()
+        result = runner.invoke(main, cmd.split(" "), catch_exceptions=False)
+        captured = capfd.readouterr()
+        assert captured.out
+        assert result.exit_code == 0
+
     def test_repeat_with_hapgts(self, capfd):
         tmp_transform = Path("temp-transform.vcf")
         with open(tmp_transform, "w") as file: